Accession Number : ADP008814

Title :   Thermoregulatory Effects of Atropine in the Cold using a Hypotrichotic Rat Model.

Corporate Author : ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Personal Author(s) : Gentile, Brian J. ; Johnson, Craig R. ; Francesconi, Ralph P. ; Hubbard, Roger W.

Report Date : 13 MAY 1993

Pagination or Media Count : 10

Abstract : The objectives of this research were to determine the effects of atropine on shivering and peripheral-vasodilation in the cold, with attendant effects on thermoregulation. A conscious, confined but unrestrained, hypotrichotic (Wistar-Furth, fuzzy) rat model was used. Electromyography (EMG) was utilized to assess the shivering response of the trapezius muscle. An EMG frequency band between 3 Hz and 1 kHz was rectified, then integrated for determination of a shivering index. Infrared thermography was used to monitor dorsal body skin temperature as an indirect assessment of cutaneous blood flow. Rats were injected in the lumbar musculature with either 1 mg/kg atropine (A) or an equivalent volume (0.15 ml) of saline (S) 30 minutes after exposure to one of three ambient temperatures (25 deg C, 18 deg C or 12 deg C) Data were then collected for an additional 90 minutes.

Descriptors :   *ATROPINE, *COLD TOLERANCE, BLOOD, BODIES, DETERMINATION, ELECTROMYOGRAPHY, MODELS, BLOOD CIRCULATION, RESPONSE(BIOLOGY), MONITORING, MUSCLES, RATS, SHIVERING, TEMPERATURE CONTROL, THERMOGRAPHY, VASODILATION.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE