Accession Number : ADP008880

Title :   Binding Parameters of Animal Toxins: Tetrodotoxin, Saxitoxin and Micro-Conotoxin on Na+ Potential-Dependant Channels of Rat Brain Homogenates and Slices.

Corporate Author : ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Personal Author(s) : Garrigue, H. ; Richer, C. ; Bouvet, O. ; Pignot, C. ; Binder, P.

Report Date : 13 MAY 1993

Pagination or Media Count : 9

Abstract : Tetrodotoxin and saxitoxin coming from a fish (fugu) and a sea dynoflagelate (alexandrium) are pharmacological tools for studying Na+ potential-dependant channels; u-conotoxin from a sea-snail shell is a short peptide (22 AA) and therefore could cross some anatomical barriers when administered by respiratory route. In such case, this toxin could eventually represent a threat. In this study, binding parameters of the three toxins were determined on rat brain homogenates and slices by autoradiography and image analysis. Some results on the toxin capability to cross respiratory system and blood brain barrier will also be presented.

Descriptors :   *AUTORADIOGRAPHY, *BLOOD BRAIN BARRIER, *BRAIN, *TOXINS AND ANTITOXINS, *PHARMACOLOGY, BARRIERS, BLOOD, CHANNELS, FISHES, IMAGES, OCEANS, PARAMETERS, PEPTIDES, RATS, RESPIRATORY SYSTEM, SNAILS, THREATS, TOOLS, ANIMALS, CARDIAC ARREST, MUSCLES, MOLECULAR WEIGHT.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE