Accession Number : ADP008899

Title :   Therapeutic Intervention Strategies for Staphylococcal Enterotoxin B-Induced Illness.

Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF PATHOLOGY

Personal Author(s) : Jett, Marti ; Hunt, Robert ; Boyle, Thomas ; Gemski, Peter

Report Date : 13 MAY 1993

Pagination or Media Count : 2

Abstract : The characteristics of Staphylococcal enterotoxin B (SEB) intoxication in monkeys and man include vomiting and diarrhea that can lead to shock and death. Experimentally in rhesus monkeys, SEB administered (Iv) caused vomiting, diarrhea, anorexia and malaise within 2-7 hr. The monkeys demonstrated no apparent illness for the following 10-20 hr; another period of mild illness occurred (for about 7 hr), then a 5 hr brief improvement. From 40-60 hr, the monkeys developed difficulty in breathing, displayed low blood pressure and symptoms of shock, and death occurred rapidly, This pattern of severe symptoms interspersed with periods of no apparent illness was also observed in accidental intoxication with SEB from undercooked eggs eaten by patients in a nursing home in Sweden R. Mollby, ISSSI 7:24-32 (1992). The apparent recovery of these patients after the first wave of illness, delayed their treatment and may have contributed to the death of several of them.

Descriptors :   *ENTEROTOXINS, *SIGNS AND SYMPTOMS, *STAPHYLOCOCCUS, *ILLNESS, *SHOCK(PATHOLOGY), ANOREXIA, BLOOD, BLOOD PRESSURE, DEATH, DIARRHEA, EGGS, EMESIS, INTOXICATION, MALAISE, MONKEYS, NURSING, PATIENTS, PATTERNS, PRESSURE, RECOVERY, RESPIRATION, RHESUS MONKEYS, SHOCK, SWEDEN, RESPIRATORY SYSTEM, INFECTIOUS DISEASES, ENDOTOXIC SHOCK, DRUGS.

Subject Categories : Pharmacology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE